AAPLAPHOR®   Castor Oil Derivatives

Aaplaphor range is non ionic solubiliser and emulsifier obtained by reacting hydrogenated castor oil with ethylene oxide. They have ability to solubalise and emulsify oils soluble ingredients like vitamins, perfumes, essential oils and other hydrophobic pharmaceuticals and covert them into clear transparent solution or stable emulsion respectively. It improves the solubility of poorly soluble drugs (BCS class II and class IV).

Aaplaphor Grades
  • AAPLAPHOR® RH-40
  • AAPLAPHOR® RH-50
  • AAPLAPHOR® RH-60
  • AAPLAPHOR® EL-35
Mechanism of AAPLAPHOR
  • Modify the polarity of water.
  • Alter various properties like density, surface tension, viscosity, boiling point and specific heat of solution in various ways.
  • Wetting the surface of salutes by lowering the contact angle between the solute and the wetting liquid.
  • Increases the solvation/hydration of solutes.
  • It solubilize the insoluble particles by converting them into small (nano) size particles with or without heating
Typical Specification

Characteristics of Aaplaphor Grades

Solubilizer

Aaplaphor range improves water solubility of major water insoluble products. It is compatible with most of the commonly used ingredients. It helps to solubilize different pharmaceutical active ingredients like Acetaminophen, Bromhexine HCL, Dextromethorphan HBr, Povidone iodine, Loxapine Succinate, Vitamins like vitamin A palmitate, vitamin D, vitamin E acetate etc.

Dissolution Improver

It is generally used 3.0% to 5.0% w/w of API to improve dissolution of poorly soluble active ingredients like Cefuroxime Axetil, Cefpodoxime proxetil, Albendazole etc. It should be mixed with API with or without heating and then dissolved in vehicle ( Aqueous / Non aqueous ).

Emulsifier

Aaplaphor range is excellent versatile emulsifying agent. It emulsifies major hydrophobic substances like fatty acids, fatty alcohols, mineral oil etc.

Moisturizer

Aaplaphor range improves moisturizing effect and soft feeling.

Transparency Improver

Aaplaphor range solubilizes insoluble oily substances in aqueous system and hence it improves transparency and shining.
In cosmetic formulations, it impacts elegance, appearance of products such as shaving gel, hair styling gel, hand wash gel etc. In pharmaceutical syrup formulations, it improves transparency.

Volatility retardant

Aaplaphor range retards volatilities of solvents. It can be used for highly volatile products like after shav lotion, perfumes etc. to retain its effect for longer period.

Film Former

Aaplaphor range improves film forming capacity and flow properties. Aaplaphor is preferred in cream, lotion, lipstick etc. to improve film forming capacity.

Masking Agent

Aaplaphor masks unpleasant taste and odor of typical formulations like pharmaceutical syrup containing alcohols and suspension like artemether and lumefantrine suspension.

Aerosol Formulations

Aaplaphor improves solubility of the propellant in aerosol in aqueous phase.